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After Stalingrad. Why Hitler turned to Soviet soldiers to save his army

After Stalingrad, Germany’s armies in the East were bleeding men faster than they could be replaced. Divisions were shrinking, fronts were cracking, and Hitler’s war machine began relying more heavily ...

What locals know about Torquay that tourists miss on Devon's English Riviera

Sadly the hotel that inspired John Cleese, when he visited with the Monty Python team in 1973, is no more. The Gleneagles was ...

The 21 Yorkshire places you didn't know were in Hollywood blockbusters

Yorkshire locations highlighted in the guide include: Castle Howard (Bridgerton); North York Moors Railway (Harry Potter, ...
eLife

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...
eLife

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

EM, biochemical, and cell-based assays to examine how Gβγ interacts with and potentiates PLCβ3. The authors present evidence for multiple Gβγ interaction surfaces and argue that Gβγ primarily enhances ...