MOPP/ABV hybrid chemotherapy for advanced Hodgkin's disease significantly improves failure-free and overall survival: the 8-year results of the intergroup trial. PK analysis was performed at first ...

Idarubicin cardiotoxicity: a retrospective study in acute myeloid leukemia and myelodysplasia. Initial phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified ...

The pharmacokinetics, safety, and tolerability of four topical lidocaine patches 5% continuously applied for 72 hours and changed every 12 or 24 hours were examined. In this randomized, prospective, ...

ADME is the abbreviation for absorption, distribution, metabolism and excretion. ADME studies are designed to investigate how a chemical (e.g., a drug compound) is processed by a living organism.

Irrespective of what therapeutic area or drug target a discovery program pursues, a common bottleneck that cannot be avoided is pharmacokinetics and safety. Thus, all drugs must enter the body, ...

In this study, an UPLC-MS/MS method with specificity and accuracy was established to simultaneously quantify aumolertinib, osimertinib, gefitinib and their major metabolites (left). By using this ...

Shenqi Fuzheng (SQ) is a widely used Chinese medicine formula known for its immune-enhancing and Qi-supplementing properties. However, the blood-absorbed components of SQ and their pharmacokinetics ...

Discovering and bringing a new drug to market typically takes 14 years and costs approximately $ 2 billion USD. Today, the competitive landscape throughout the drug development process requires ...